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Chlorpheniramine Maleate

Why has my veterinarian prescribed this medicine?

Chlorpheniramine maleate is an antihistamine. Antihistamines are used to relieve or prevent the symptoms of allergy. Your veterinarian may prescribe this medication to prevent itching in cats. It may also be beneficial for managing cats that excessively groom themselves.

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How do I give this medication?

  • Give this medication to your pet as directed by your veterinarian. READ THE LABEL CAREFULLY.
  • This medication may be given with food.
  • If the medicine is a liquid, measure the dose with reasonable care.
  • Try to give this medication at about the same time(s) each day.
  • DO NOT give the pet more medicine than directed.
  • DO NOT give the medicine more often than directed.
  • Try not to miss giving any doses.

What do I do if I miss giving a dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give the pet two doses at once.

How do I store this medicine?

  • Keep this medicine out of reach of children.
  • Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight.
  • Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.

What are the potential side effects?

  • The most common side effect is drowsiness. This effect may decrease with time.
  • Your pet may experience some stomach upset, such as diarrhea, vomiting and lack of appetite. If these symptoms persist, contact your veterinarian.
  • Your pet may experience dry mouth and retain its urine for longer than usual. Notify your veterinarian if these effects are troublesome and continue.
  • Cats may become agitated or excited when taking this medication
  • Other side effects may occur. If you notice anything unusual, contact your veterinarian.

Are there any possible drug interactions?

  • Make sure to tell your veterinarian what other medication you are giving to your pet.
  • Quite often, your veterinarian may prescribe two different medications, and sometimes a drug interaction may be anticipated. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.
  • The following drugs can potentially interact with chlorpheniramine maleate: phenytoin, heparin, warfarin and other CNS depressants.
  • Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Last updated on Jul 8, 2016.